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School of Life Dentistry at Tokyo
The Graduate School of Life Dentistry at Tokyo and that at Niigata were established in April 1960 and April 1990, respectively. The schools' objectives are, first, to conduct research on and April 1990 training in dental theory and practice; second, to give students a high degree of expertise to enable them to contribute to advances in dentistry; third, to provide training in a broad spectrum of research fields so students can practice in many places, such as in international research institutions. A unique curriculum has been introduced that is free of preconceived or conventional ideas and integrates both basic studies and clinical practice. New research facilities as well as those for collaborative research are available for the students' use, and many students who complete the graduate course remain at the university for further research while teaching undergraduates.
The principal research content of the research department at the Nippon Dental University School of Life Dentistry at Tokyo.
Major Subject Programs (Director)
Themes of Study
Anatomy
Meso-scale anatomical analysis of vascular network patterning in the maxillofacial
region
Analysis of molecular mechanisms in the vessel formation and angiogenesis
process during tooth germ development
Analysis of structural changes in three-dimensional micromorphology during
growth and development of the maxillary and mandibular bone
Histology
Histochemistry research on embryology and differentiation of the salivary
gland
Cytohistologic research on injury and recovery of the salivary gland
Aging research of the salivary gland
Physiology
Effect of oral and maxillofacial perception and/or motor activity on body
functions
Taste sensation and the cognitive processing in human subjects
Research on physiological homeostasis ; influence of environmental fuctors
on respiration, circulation and metabolism
Biochemistry
Analysis of signal transduction and gene transcription mechanisms in cancer
tissue
Molecular biological analysis of keratinocyte differentiation and dedifferentiation
mechanisms
Analysis of mechanisms related to the development and progression of non-neoplastic
diseases
Pathology
Multifaceted structural/functional analysis of human oral lesions
Comparative pathological analysis of oral diseases in animal models
Molecular network analysis of maxillofacial development and the pathogenesis
of congenital anomalies
Microbiology
Research on the pathogenicity of oral streptococci in infectious endocarditis
Molecular biological analysis on the pathogenetic factors of the causative
agents of chronic periodontitis
Molecular biological analysis on the pathogenetic factors of the causative
agents of aggressive periodontitis
Pharmacology
Functional analysis of oral stem cells.
Development of tooth and dental pulp regeneration techniques
Investigation for the safety and efficacy of medicines
Oral Health
Liver, heart, and pancreas regeneration by dental pulp stem cells and volatile
sulfur compounds
Transplantation of regenerated liver or pancreas from human dental pulp
Research on childhood and pediatric health behavior, daily life behavior,
and prevention of lifestyle-related diseases
Research on the periodontal-disease-causing activity and carcinogenicity
of volatile sulfur compounds (halitosis substances)
Dental Materials Science
Dental application of intraoral scanner and it’s precision
Applications of novel monomers to the composite resin and adhesive resin
cement
Research on the composition and physical properties of dental materials
Dental application of CAD/CAM technique
Dental applications of 3D printers
Tissue Engineering & Regenerative Medicine
Isolation, characterization, and differentiation of multipotent stem cells
derived from human teeth
Engineering of test-tube dental implants for regenerative therapy
Cell and molecular biology of tooth/periodontal development and regeneration
Forensic Dentistry
Recognition, prevention of physical abuse and neglect, and child care support
Personal dental identification
Disaster dentistry
Major Subject Programs (Director)
Themes of Study
Endodontics
Research and development of endodontic equipments, instruments and materials
Research on root canal preparation and root canal obturation methods
Research on regeneration and healing of the dental pulp and apical periodontal
tissue on endodontic diseases
Research on accuracy of radiographical examination on endodontic diseases
Immunohistochemical research on generation and development of tooth and
jawbone
Removable Prosthodontics
Relationship between the brain, sleep, or pain mechanisms and masticatory
function and occlusion
Relationship between masticatory function and occlusion
Establishment of prosthodontic treatment adapted to masticatory function
Crown & Bridge Prosthodontics
Clinical application of glass-fiber-reinforced hybrid resin restorative
materials
Computer-supported examination, diagnosis, and restorative appliance system
Adhesion techniques and CAD/CAM esthetic restorations
Oral and Maxillofacial Surgery
Research of local invasion and metastasis of oral squamous cell carcinoma
Research of relationship between cancer stem cell and tumor associated
macrophage of oral squamous cell carcinoma
Tissue regeneration program that uses growth factors and biomaterials
Research and development of new tissue regeneration therapies from human dental pulp stem cells
Orthodontics and Dentofacial Orthopedics
Three-dimensional morphometric analysis of dental arch form
Clinical study in treatment mechanics of preadjusted appliances
Genetic origin of dental anomalies
Evaluation of facial esthetics in orthodontic treatment
Three-dimensional biomechanics of orthodontic force
Oral and Maxillofacial Radiology
Research on image diagnosis for maxillofacial region
Research related to radiation protection during radiological examinations
Research on image quality of the CBCT examination
Research on computer aided diagnosis in dentistry
Research on ultrasound-guided nerve ganglion block
Pediatric Dentistry
Emotional response in children during dental treatment
Prevention of oral diseases in childhood
Dental development in children with systemic diseases
Dental Anesthesiology
Research on the disposition and potency of local anesthetics
Application of α2 receptor agonists in the dental anesthesia field
Research on ambulatory anesthesia: Drugs, evaluation, techniques, etc.
Periodontology
Research on the relationship between periodontal disease and systemic disease
Research on the effects of smoking on periodontal tissue
Research on the new examination for periodontal diseases
Epidemiological research on periodontal diseases
Application of LED and lasers to periodontal treatment
Research on the pathological condition improving factor for periodontal
disease
Adhesive Dentistry
Evaluation for the behavior of metal-free adhesive restorations in in vivo and in vitro environments
Development and evaluation of novel restoration methods and materials to
contribute the next generation MI esthetic restorations
Comprehensive investigation of the innovative digital restoration system
Revitalization of bio-adhesion for the affinity of tooth substance
Clinical Oral Rehabilitation
Research on eating and swallowing rehabilitation
Research on the development or disorder of eating function
Research on the relation between the oral function of the elderlies and
their whole body
Epidemiological research on community-dwelling elderlies